Biomimetic dense lamellar scaffold based on a colloidal complex of the polyaniline (PANi) and biopolymers for electroactive and physiomechanical stimulation of the myocardial

Abstract A novel biodegradable conductive scaffold containing water-soluble polyaniline (PANi) was manufacture. The conductive dense lamellar scaffolds were obtained by a mixture of collagen, fibroin solution, hyaluronic acid, and water-soluble polyaniline, using plastic compression method. Scaffolds held open and interconnected pores having a pore size ranging from several 100 to 150 µm. PANi-scaffolds had compression modulus and strength of 1.77 ± 0.11 MPa. The isoelectric point of the scaffold was observed by surface zeta potential in pH 7.7. The conductivity of the scaffold was measured as 2.10-6 S.cm -1 for dry PANi-scaffold and 6.10-4 S. cm -1 for hydrated. The PANi-scaffold has physiomechanical, and physico-chemical properties supported the viability and proliferation of cardiomyocytes. Our results highlight the potential of incorporation of PANi as an electroactive moiety for induction of cardiomyocyte proliferation and repair of damaged heart tissue.