TWO MITOCHONDRIAL ENZYMES IN PLATELETS OF PATIENTS WITH ENDOGENOUS PSYCHOSES

Aim – testing hypothesis on co-regulation between glutamate and energy metabolism mitochondrial enzymes (glutamate dehydrogenase (GDH) and cytochrome c-oxidase (COX), respectively) [1-3]. Methodology – enzymatic activities of GDH and COX in platelet mitochondria of patients (schizophrenia SCH, n=55, schizoaffective disorder, SAD, n=22) are measured before and after treatment course and compared with control group (n=38). Results – significantly decreased levels of GDH and COX activities are found in patients in comparison with controls (p<0.05). GDH and COX levels are found normally distributed in all studied groups (controls, SCH, SAD). Significant correlations between GDH and COX activities are found in all studied groups (p<0.05). Linear regression coefficients a and b (in the equation y=a+b*x, wherein y=GDH, and x=COX activities, respectively) are found different in dependence on diagnosis and changed after antipsychotic treatment. Conclusion – correlation between GDH and COX activities suggests co-regulation of these enzymes, its impairment in psychosis, with restoration and approaching to control values after antipsychotic treatment in SCH group.