Synthesis of 6-(4-(4-propoxyphenyl) piperazin-1-yl)-9H-purine derivatives as antimycobacterial and antifungal agents: In-vitro evaluation and in-silico study.
2020
A series of novel alkyl substituted purines were synthesized. 6-(4-(4-propoxyphenyl) piperazin-1-yl)-9 H -purine was used as the key starting material, which was synthesized via a multistep protocol and finally subjected for N-alkylation with various alkyl halides with an aim to get prospective antimicrobial agents. The structures of the novel compounds were established by substantiating them through spectral techniques like 1 H NMR, 13 C NMR, FT-IR and EI-MS. They were explored for antitubercular activity against Mycobacterium tuberculosis H37RV. Furthermore, they were checked for their antimicrobial activity concerning bacterial and fungal strains. The title compounds exhibited considerable antimicrobial activity without any significant toxicity. In-silico studies depicted their good binding profile against Mycobacterium tuberculosis enoyl reductase (InhA) (PDB ID: 4TZK) and Candida albicans dihydrofolate reductase (PDB ID: 1AI9). The title compounds obeyed Lipinski's parameters and have exhibited good drug-like properties.
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