Role of ACE2-Ang(1-7)-Mas axis in pathogenesis of kidney disease

The renin angiotensin system (RAS) plays an important role in the development of kidney disease,especially high expression in local RAS[1].Along with the further research of RAS gradually,a new RAS was found besides the classical RAS:Angiotensin Converting-Enzyme 2-Angiotensin(1-7)-Mas receptor axis (ACE2-Ang(1-7)-Mas axis).Interacted with the classical RAS,they regulate the internal environmental stability and maintain normal renal function[2].This review will focus on the role of ACE2-Ang(1-7)-Mas axis in the physiology and the pathogenesis of kidney disease.