ID: 46: APRIL increase is related to Antibodies production and clinical manifestations during Behçet disease: A study in Algerian patients

Behcet disease (BD) is a systemic chronic inflammatory disorder frequent in Algeria. As Behcet disease is considered as a vasculitis, we assessed the levels of circulating B cells by flow cytometry, antibodies (IgM, IgA, IgG) by nephelometry and auto-antibodies (ANCA, APLs) by Luminex in 70 patients with BD and 20 control subjects. The obtained results were analyzed by Mann Witney U test. We observed a significant increased B cells and antibodies levels in comparison to control group ( p 0.01 ). Patients showed different profile according to the clinical data (activity: p 0.05 , clinical expression: p 0.01 ). Autoantibodies indicated different profiles with no differences with controls in ANCA levels ( p  > 0.05). In contrast, anti-phospholipids were higher during BD with aCL (anticardiolipins) revealing a significant difference ( p r  = 0.760, p p