Abstract 15468: Age- and Gender-specific 99th Percentile Cut-offs for Diagnosis of Myocardial Infarction and Prognostic Implications - Results From the High Sensitivity Cardiac Troponin T Assay for Rapid Rule-out of Acute Myocardial Infarction Substudy

Objective: We aimed to evaluate the impact of age- and gender-specific cut-offs in comparison to the general 99th percentile cut-off for diagnosis and prognosis of acute myocardial infarction (AMI). Methods: 1282 unselected patients presenting with suspected AMI and recent (<6h) onset of chest pain to the emergency department were enrolled as part of the TRAPID-AMI study and 359 patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) qualified for further subanalysis. Patients were classified using age- and gender-dependent hs-TnT 99th percentile cut-off values previously described in literature (28 ng/L for ≥65y, 9 ng/L for female and 15.5 ng/L for male patients) in comparison to the general cut-off of 14 ng/L. Results: Table 1 displays changes regarding diagnostic reclassification and outcomes when comparing age-specific and general 99th percentile cut-off values in NSTE-ACS patients with age ≥65y (n=216). Significant reclassification concerning 1-month and 3-month mortality could be observed ...