The Effects of N-Terminal Part Modification of Arginine Vasopressin Analogues with 2-Aminoindane-2-carboxylic Acid: A Highly Potent V2 Agonist

In this study we present the synthesis and some pharmacological properties of nine new analogues of arginine vasopressin modified in the N-terminal part of the molecule with 2-aminoindane-2-carboxylic acid (Aic). The peptides were tested for their in vitro uterotonic and in vivo pressor and antidiuretic activities. One of the new peptides, [Mpa 1 ,Aic 2 ,Val 4 ,D-Arg 8 ]VP, exhibited an antidiuretic activity similar to that of [Mpa 1 ,D-Arg 8 ]VP, thus being one of the most potent antidiuretic vasopressin analogues reported to date.