belladonna/(lhx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain
2006
Some of the earliest axon pathways to form in the vertebrate forebrain are
established as commissural and retinal axons cross the midline of the
diencephalon and telencephalon. To better understand axon guidance in the
forebrain, we characterized the zebrafish belladonna ( bel )
mutation, which disrupts commissural and retinal axon guidance in the
forebrain. Using a positional cloning strategy, we determined that the
bel locus encodes zebrafish Lhx2, a lim-homeodomain transcription
factor expressed in the brain, eye and fin buds. We show that
bel(lhx2) function is required for patterning in the ventral
forebrain and eye, and that loss of bel function leads to alterations
in regulatory gene expression, perturbations in axon guidance factors, and the
absence of an optic chiasm and forebrain commissures. Our analysis reveals new
roles for lhx2 in midline axon guidance, forebrain patterning and eye
morphogenesis.
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