Expression changes of Survivin, BCRP and HER-2 genes after neoadjuvant chemotherapy of NE in breast cancer
2011
Objective To investigate Survivin,BCRP and HER-2 genes prediction and sensitivity of breast cancer in neoadjuvant chemotherapy with NE ( Vinorelbine and Epirubincin).Methods There were 46 cases of breast cancer patients with neoadjuvant chemotherapy NE program,using reverse transcription-polymerase chain reaction (RT-PCR) method to detect Survivin,BCRP and HER-2 expression before and after chemotherapy and to analyze the differences in the relationship with chemotherapy.Results Neoadjuvant chemotherapy NE overall response rate was 76.1% (35/46),which cCR accounted 15.2% (7/46),pCR 10.9% (5/46),cPR 60.9% (28/46),SD 21.7% (10/46),PD 2.2% (1/46),respectively.After chemotherapy,positive expression rates of Survivin mRNA,BCRP mRNA and HER-2 mRNA decreased,the difference was statistically significant ( P < 0.05).The efficient rate of the individual positive expression of Survivin mRNA,BCRP mRNA and HER-2 mRNA were lower than the negative groups ( P < 0.05 ),three indicators of negative expression with chemotherapy were lower than other groups ( P < 0.05).There was no relationship among the expression of Survivin mRNA,BCRP mRNA and HER-2 mRNA in breast cancer (P > 0.05).Conclusion The combined of detection the expression of Survivin,BCRP and HER-2 in NE program is helpful to predict sensitivity of neoadjuvant chemotherapy in breast cancer.
Key words:
Breast cancer; Neoadjuvant chemotherapy; Survivin mRNA; BCRP mRNA; HER-2 mRNA; Prediction; NE chemotherapy
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