Combination of Frailty Status and Comorbidity Score Improves the Stratification of Survival in Patients with Myelodysplastic Syndrome Due to Good Predictive Capability for Infection-Related Mortality

Abstract Background We investigated the prognostic effects of frailty and its association with comorbidity in patients with myelodysplastic syndrome (MDS). Methods This retrospective analysis included 118 consecutive patients diagnosed with MDS. Frailty was evaluated using the clinical frailty scale (CFS). Comorbidity was classified using the Charlson comorbidity index (CCI) and MDS comorbidity index (MDS-CI). Results On multivariate analysis, CFS (≥ 5 vs. Conclusion The present study suggests frailty and comorbidity may be patient-related, independent predictive factors of poor prognosis. This could probably be attributed to increasing infection-related mortality with frailty and comorbidity. Combining the evaluation of frailty and comorbidity to IPSS-R might aid in more precise prediction of OS, especially in patients with low risk of MDS.