Halogen and nucleoside derivatives of acyclic 2-amino-2-deoxy-D-glucose. III☆☆☆

Abstract 3,4,5,6-Tetra- O -acetyl-2-deoxy-2-(trifluoroacetamido)- D -glucose diethyl dithioacetal was treated with bromine to give the 1-bromo-1- S -ethyl derivative, which was condensed with bis(trimethylsilyl)thymine to afford a pair of C-1 epimeric, acyclicsugar nucleoside analogs. Deacylation of these two compounds with methanolic ammonia gave the 2-amino-1,1,2-trideoxy-1-(ethylthio)-1-thymin-1-yl- D -glucose aldehydrols, isolated as their hydrochlorides.