Antioxidative polyphenolics obtained from spent coffee grounds by pressurized liquid extraction

Abstract Spent coffee grounds are produced in huge amount by cafeterias, restaurants and industries, which could be a good natural antioxidants resource. In this study, extraction conditions for total phenolics and caffeine from spent coffee grounds were optimized by pressurized liquid extraction (PLE) method with water and ethanol using statistical experimental design. The process was optimized by Plackett–Burman design to screen the most important variables for the extraction of total phenolics and caffeine firstly, and then central composite design (CCD) was performed to obtain the optimum conditions of the preferential factors for extraction. Temperature and weight of sample loading influenced the extraction efficiency of total phenolics and caffeine at 95% level (P