Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype

Xiaolan Zhu,Huiling Shen,Xinming Yin,Meiling Yang,Hong Wei,Qi Chen,Fan Feng,Yueqin Liu,Wenlin Xu,Yuefeng Li

Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype

2019

Xiaolan Zhu
Huiling Shen
Xinming Yin
Meiling Yang
Hong Wei
Qi Chen
Fan Feng
Yueqin Liu
Wenlin Xu
Yuefeng Li

Background How exosomal microRNAs (miRNAs) derived from macrophages contribute to the development of drug resistance in the context of the hypoxic tumor microenvironment in epithelial ovarian cancer (EOC) remains poorly understood.

Keywords:

mir-223
Cancer research
Drug resistance
Ovarian cancer
Tumor microenvironment
Microvesicles
Biology
Phenotype
microRNA
Apoptosis
Exosome
Cell
Akt/PKB signaling pathway
PI3K/AKT/mTOR pathway
PTEN

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