Clinical and Biochemical Features of Seven Adult Adrenal Ganglioneuromas
2010
Background: Adrenal ganglioneuroma (GN) is seldom considered in the differential diagnosis of adrenal lesions, and its clinical presentation is not well known. Objective: Our aim was to describe the clinical, biochemical, and radiological features of adrenal GNs in adults. Methods: Seven adults underwent endocrine investigation for adrenal lesions that were confirmed to be adrenal GNs. Results: Mean age of the seven patients was 49 yr (range, 23 to 71 yr). Average tumor diameter was 5.0 cm (range, 1.5 to 10.4 cm). In five patients, the adrenal lesions were found incidentally. A 49-yr-old female carried a germline mutation in MSH2 gene. A 57-yr-old female presented with mild virilization and increased testosterone levels. Bilateral adrenal venous sampling revealed testosterone production from her right adrenal lesion. All tumors showed nonenhanced attenuation between 25 and 40 Hounsfield units on computed tomography scan. Magnetic resonance imaging revealed low- to iso-signal intensity on T1-weighted imagi...
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