Regulation of Memory Cd4 T Cells: Generation, Localization and Persistence

Over the past few years several studies have influenced how we think about the generation and persistence of T cell memory. First, our studies have shown that CD4 memory T cells can be derived from effector cells, without further division.1,2This implies that the differentiation events that are heritable and accompanied by epigenetic remodeling, all take place during the effector generation stage. Our results and those from Bradley’s laboratory, further indicate that an important component of memory generation from effectors is the removal of antigen and cytokines which causes this transition.2,3.