Enantioselective Synthesis of Monocyclic β-Lactams Related to Nocardicins via a (2+2) Cycloaddition Reaction.

Monocyclic β-lactams related to nocardicins were enantioselectively synthesized from phthal-imidoacetyl chloride and hexahydro-1, 3, 5-triazines (4) via a [2+2] cycloaddition reaction. The preparation and biological activity of some typical acyl derivatives are also described.