A REVIEW ON SPHERICAL CRYSTALLIZATION: A NOVEL PARTICLE DESIGN TECHNIQUE FOR DIRECT COMPRESSION OF PHARMACEUTICAL POWDERS

Direct compression of powders is simplest and easiest way of making tablets. Good flowability and compressibility plays a major role for direct compression of drugs. There are several techniques available to impart desired compressibility to drugs. Spherical crystallization techniques are reliable techniques in which the drug crystals are modified using different solvents to directly compressible spherical agglomerates, which less economical and time saving. The use of spherical crystallization as a technique appears to be efficient alternative for obtaining suitable particles for direct compression. Spherical crystallization is a particle design technique, by which crystallization, agglomeration and spheronization can be carried out simultaneously in one step.