Asymmetric Synthesis of trans-(2R,5R)-Bis(benzyloxymethyl)pyrrolidine.

Abstract Trans-(2R,5R)-bis(benzyloxymethyl)-pyrrolidine ( 1 ) was prepared from 1,2:5,6-diisopropylidene mannitol. Key transformations included the selective protection of primary hydroxy groups and stereocontrolled cyclization.