Association of iron overload (IO) with time to progression (TTP) in patients with multiple myeloma (MM) undergoing autologous hematopoietic stem cell transplant (HSCT).

e17003 Background: IO resulting principally from red blood cell (RBC) transfusions is not an uncommon complication in HSCT recipients. Organ dysfunction and increased risk of infection associated with IO in early post-transplant period is increasingly being reported. Long-term effects of IO including risk of relapse/progression are less well described. Methods: A retrospective chart review identified 26 patients diagnosed with MM and treated with high-dose melphalan (200 mg/m2) followed by autologous HSCT at our institution from 1999 to 2007. Patients with serum ferritin level (F) 1,000 ng/dl, measured at steady state (3–24 mos post transplant), were compared regarding demographics, disease stage, disease type, end organ complications, β-2 microglobulin, presence of adverse chromosomal abnormalities, RBC transfusion history and TTP as measured by the international myeloma working group criteria. Results: Results are shown in the Table. Five patients had F>1000 ng/dL and 21 <1,000 ng/dL with median...