Association of long-term heavy aluminum intake and involuntary movements with cognitive decline

predictors. Meta-analysis was performed to develop a DRA point score based on the predictors retained in the final model. Results: The final DRA tool included age (1 point/year), <12 years education (9 points), stroke (6 points), diabetes mellitus (3 points), bodymass index<18.5 kg/m 2 (8 points), requiring assistance with money/medications (10 points), and evidence of depression (anti-depressant use/self-reporting "everything an effort" 3 days/ week, 6 points). Accuracy based on Harrell’s c statistic (95% confidence interval) was CHS, 0.68 (0.65, 0.72); FHS, 0.77 (0.73, 0.82); HRS, 0.76 (0.74, 0.77); and SALSA, 0.78 (0.72, 0.83). Across all 4 studies, a point-value of 22 identified a group of 65-79 year-olds whose 6-year dementia risk was comparable to 80-84 year-olds. Conclusions: The DRA is a simple tool that can be used in primary care to identify older patients with an increased risk of developing dementia who should be considered for cognitive screening.