Discovery of N-(1-adamantyl)-2-(4-alkylpiperazin-1-yl)acetamide derivatives as T-type calcium channel (Cav3.2) inhibitors

Abstract Chemical evolution of a HTS-based fragment hit resulted in the identification of N -(1-adamantyl)-2-[4-(2-tetrahydropyran-4-ylethyl)piperazin-1-yl]acetamide, a novel, selective T-type calcium channel (Ca v 3.2) inhibitor with in vivo antihypertensive effect in rats.