Chapter 31. To Market, To Market -1988

Publisher Summary During 1988, 20 new chemical entities were approved in the United States and 29 reached the marketplace, including α-1 anti-trypsin, apraclonidine hydrochloride, octreotide, and pergolide mesylate that were also first worldwide launches. Every product described in the chapter has been categorized as antihypertensive, antihistamine, antimigraine, antiglaucoma, antibiotic, gastroprokinetic, vasoprotective, cardiostimulant, hematopoietic, nootropic, antifungal, antitussive, abortifacient, etc. Every product description has been classified under several fields, such as product name, trade name, first introduction, introduced by, country of origin, originator, and CAS registry no. Acrivastine is an orally-active H 1 .receptor antagonist is reportedly useful in the treatment of allergic rhinitis. Alacepril is an angiotensin-converting enzyme (ACE) inhibitor useful in the treatment of essential and renal hypertension. Alpiropride is a sulpiride-like dopamine antagonist reportedly useful in the treatment of migraine. Alpraclonidine hydrochloride is a selective α-adrenergic agonist useful in the postsurgical control of intraocular pressure with minimal systemic side-effects. Enoximone is a phosphodiesterase inhibitor indicated for selective use as a cardiostimulant in heart transplant patient maintenance. Exifone is a nootropic indicated for the treatment of cognitive dysfunctions in geriatric patients. Fluconazole is the first member of a new generation of stable and orally active antifungals, the triazoles. It is highly effective in the treatment of dermal and vaginal fungal infections. Flutropium bromide is an anti-tussive, useful in the treatment of allergic rhinitis and in the symptomatic relief of bronchial asthma and chronic bronchitis. Mifepristone is an orally-active progesterone and glucocorticoid receptor antagonist indicated for use as a post-coital contraceptive. The way these new chemical entities (NCEs) were marketed was worth enough to make most of these products of use by people all over the world.