Novel Steroidal Vinyl Fluorides as Inhibitors of Steroid C17(20) Lyase

Joseph P. Burkhart,Philip M. Weintraub,Cynthia A. Gates,Robert J Resvick,Roy J. Vaz,Dirk Friedrich,Michael Angelastro,Philippe Bey,Norton P. Peet

Novel Steroidal Vinyl Fluorides as Inhibitors of Steroid C17(20) Lyase

2002

Joseph P. Burkhart
Philip M. Weintraub
Cynthia A. Gates
Robert J Resvick
Roy J. Vaz
Dirk Friedrich
Michael Angelastro
Philippe Bey
Norton P. Peet

Abstract 20-Fluoro-17(20)-pregnenolone derivatives were designed as enol mimics of pregnenolone. All of the targeted, novel fluoroolefins were potent inhibitors of C 17(20) lyase.

Keywords:

Enzyme
Organic chemistry
Chemical synthesis
Enol
Lyase
Biochemistry
Pregnenolone
Chemistry
Enzyme inhibitor
Steroid
In vitro
Stereochemistry

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