Regioselective Synthesis of Novel FunctionalizedPyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5]triazaphosphepines
2021
The reactions of
6-acetyl-3-amino-4-imino-7-methyl-5-phenyl-3,5-dihydro-4H-pyrano[2,3-d]pyrimidine with triethyl phosphite and some electrophilic
reagents, namely 1,2-dibromoethane, oxalyl chloride, chloroacetyl chloride, and
ethyl chloroacetate, were studied. These one-pot three-component reactions
regioselectively afforded four new
11-acetyl-2-ethoxy-10-methyl-12-phenylpyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5λ5]triazaphosphepin-2-ones in
69–73% yields.
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