Erythrocyte Glutathione-Peroxidase Deficiency

Summary Glutathione peroxidase deficiency is the most recently described erythrocyte enzyme abnormality. This enzyme occupies a critical position in the pathways leading to the decomposition of peroxides in the erythrocyte. On the basis of our studies of patients with GSH-P deficiency, it appears that a spectrum of disease quite similar to that found in G-6-PD deficiency is present; this includes compensated haemolytic disease, drug-induced haemolysis and neonatal jaundice.