A clinical study of insulin resistance in patients with chronic pancreatitis

Abstract Objective Insulin resistance (IR) and beta cell dysfunction are the pathophysiological determinants of the diabetes mellitus (DM). We investigated the presence of IR in patients with chronic pancreatitis (CP) and compared the same with the underlying etiology. Methods In this cross-sectional, observational study, we included serial patients of CP presented to our hospital. The study population is in different stages of CP and are grouped as alcoholic CP (Group 1; N = 67) and tropical CP (Group 2; N = 35). IR was estimated by the homeostasis model assessment (HOMA) method. The results were analyzed by appropriate statistical methods. Results The study participants (85 M and 17F) had a mean age 40.8 ± 12.6 yr, CP duration 3.7 ± 4.7 yr and body mass index (BMI) of 22.5 ± 3.2 kg/m 2 . DM was seen in 54 patients with average glycosylated hemoglobin of 7.5 ± 1.6%. A total of 9 patients had HOMA-IR more than 3 suggestive of IR with no significant difference between the two groups. The duration of the DM correlated negatively with glycemic parameters and BMI showed a positive correlation with the fasting insulin and HOMA-IR. Conclusion IR was seen in a minority of patients with CP and is not a significant contributor to the pancreatogenic diabetes.