Parasite histones mediate blood-brain barrier disruption in cerebral malaria.

Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection. Despite effective antimalarial drugs, 10–20% of children developing CM die, contributing to 400,000 malarial deaths per year, mostly in children in sub-Saharan Africa.[1,2][1] A defining feature of CM is the