Protection against hemorrhagic shock in the cat by human plasma containing endotoxin-specific antibodies

Abstract Units of plasma in a blood bank were screened by an immunoprecipitin procedure to find plasma samples rich in antiendotoxin antibodies. Approximately 7% of these units had antiendotoxin antibody concentrations of 40 μg/ml or greater. Such human plasma, after absorption of agglutinin(s) was infused into cats who were in a lethal hemorrhagic shock. Survival was improved in those cats who received antibody-rich plasma compared to that in controls. Thus immunotherapy may possibly be clinically useful in treating nonseptic as well as septic shock.