INVITED EDITORIAL A New Twist: Some Patients with Saethre-Chotzen Syndrome Have a Microdeletion Syndrome

One of us (E.H.Z.), as a fellow with Dr. Roy Breg, pub-lished a paper regarding a child who had unicoronalsynostosis, unilateral ptosis, short stature,microcephaly,simian crease, developmental delay, and a ring chro-mosome 7 (Zackai and Breg 1973). Twenty-five yearslater, after reading Johnson and colleagues’ paper in thisissue of the