Polynomials under Ornstein–Uhlenbeck noise and an application to inference in stochastic Hodgkin–Huxley systems
2020
We discuss estimation problems where a polynomial
$$s\rightarrow \sum _{i=0}^\ell \vartheta _i s^i$$
with strictly positive leading coefficient is observed under Ornstein–Uhlenbeck noise over a long time interval. We prove local asymptotic normality (LAN) and specify asymptotically efficient estimators. We apply this to the following problem: feeding noise
$$dY_t$$
into the classical (deterministic) Hodgkin–Huxley model in neuroscience, with
$$Y_t=\vartheta t + X_t$$
and X some Ornstein–Uhlenbeck process with backdriving force
$$\tau $$
, we have asymptotically efficient estimators for the pair
$$(\vartheta ,\tau )$$
; based on observation of the membrane potential up to time n, the estimate for
$$\vartheta $$
converges at rate
$$\sqrt{n^3\,}$$
.
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