Prognostic factors in severe eosinophilic asthma in children

Introduction: Uncontrolled severe eosinophilic asthma (SEA) represents a health problem. Knowing the variables that predict poor control could improve the management. Objective: To identify factors of poor control of SEA. Methods We studied 27 children with SEA, collecting: pulmonary function, FENO, exacerbations, treatment, atopy, anthropological and ENT data. Sputum cellularity, eosinophils (eos) and periostin in serum, IL in serum and sputum, and ILC in peripheral blood were analyzed. Results: Characteristics of the patients are in Table 1. 55% had uncontrolled asthma, with worse quality of life, more symptoms and sensitization to mite, less to grass. We analysed differences according to the cause of poor control. There was statistically significant positive correlation between FEV1% and IL-5 and IL-9; and negative with ICS, ILC-1 and IL-8. Patients with exacerbations had statistically significant (p Conclusions: Children with uncontrolled SEA have worse quality of life, more symptoms and a trend NS to more neutrophils in sputum. Predictive factors are different, depending on the variable of poor control. Exacerbation is associated to increased eos in sputum. FEV1% was inverse correlated with TH1 inflammation.