Effects of Stimulus Intensity on Multifocal Electroretinograms

PURPOSE: To investigate origins of responses of the second order kernel components of multifocal electroretinograms (m-ERGs), the influence of stimulus intensities on the waveform were studied. SUBJECTS AND METHODS: M-ERGs were recorded from 20 normal eyes of 14 normal adults using a Visual Evoked Response Imaging System with 19 hexagonal stimulus elements with light intensities of 6.3, 20, 63, 200, or 331 cd/m2. The response densities and implicit times of the first (N1, P1, N2) and the second order kernel components (P1, N1, P2, N2, P3, N3) of the m-ERGs were measured. RESULTS: The components were divided into two groups based on the behavior of the each component to the stimulus intensity change. The first group consisted of all the first order kernel components and P1 and N1 of the second order kernel components whose response densities were significantly larger (p < 0.05) than those of components elicited by stimulus of one grade lower intensity. The second group consisted of N2, P3, and N3 of the second order kernel components whose response densities did not increase when the stimulus intensity was increased from 200 to 331 cd/m2. CONCLUSION: It is probable that in the second order kernel components, the origin of P1, N1, and P2 is different from N2, P3, and N3 because the response to stimulus intensity of the two groups of components was different.