Temporal heterogeneity of intratumoral 18F-FDG accumulation in untreated lung cancers in patients

1396 Objectives We previously reported in a mouse model of non-small cell lung cancer A549 cells and HTB177 cells, untreated lung cancers growing in animals showed fast change in intratumoral distribution of 18F-FDG during as short as 24h interval indicating glucose dynamically changed metabolism was in untreated lung cancer (J Nucl Med. 2013; 54 (Supplement 2):571). The objective of this study was to observe the preclinical findings in untreated lung cancer in patients. Methods This study had been approved by the institutional review board of Inner Mongolia Medical University. Repeated 18F-FDG PET/CT scans were performed during 3d interval in 25 Chinese patients with untreated lung cancer which was histologically conformed. Results Intratumoral 18F-FDG accumulation was spatial heterogeneity, repeated 18F-FDG PET scans revealed apparent change in intratumoral 18F-FDG distribution in as short as 24h-48 h in patients, indicating temporal heterogeneity of glucose metabolism. Conclusions Untreated lung cancers growing in patients show fast change in intratumoral distribution of 18F-FDG during as short as 24-18h interval, therefore, glucose metabolism is dynamically changed in lung cancer even without treatment. The relationship between change in intratumoral 18F-FDG accumulation and patient outcome is under investigating. Research Support Inner Mongolia Natural-Science foundation 0021835.