D-Index–Guided Early Antifungal Therapy Versus Empiric Antifungal Therapy for Persistent Febrile Neutropenia: A Randomized Controlled Noninferiority Trial

Yoshinobu Kanda,Shun-ichi Kimura,Masaki Iino,Takahiro Fukuda,Emiko Sakaida,Tatsuo Oyake,Hiroki Yamaguchi,Shin-ichiro Fujiwara,Yumi Jo,Akinao Okamoto,Hiroyuki Fujita,Yasushi Takamatsu,Yoshio Saburi,Itaru Matsumura,Jun Yamanouchi,Souichi Shiratori,Moritaka Gotoh,Shingen Nakamura,Kazuo Tamura

D-Index–Guided Early Antifungal Therapy Versus Empiric Antifungal Therapy for Persistent Febrile Neutropenia: A Randomized Controlled Noninferiority Trial

2020

Yoshinobu Kanda
Shun-ichi Kimura
Masaki Iino
Takahiro Fukuda
Emiko Sakaida
Tatsuo Oyake
Hiroki Yamaguchi
Shin-ichiro Fujiwara
Yumi Jo
Akinao Okamoto
Hiroyuki Fujita
Yasushi Takamatsu
Yoshio Saburi
Itaru Matsumura
Jun Yamanouchi
Souichi Shiratori
Moritaka Gotoh
Shingen Nakamura
Kazuo Tamura

PURPOSEEmpiric antifungal therapy (EAT) is recommended for persistent febrile neutropenia (FN), but in most patients, it is associated with overtreatment. The D-index, calculated as the area surrou...

Keywords:

Febrile neutropenia
Antifungal
Physical therapy
Medicine
Internal medicine
MEDLINE

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