Use of a particulate extracellular matrix bioscaffold for treatment of acquired urinary incontinence in dogs

Objective—To evaluate use of a particulate bioscaffold consisting of the extracellular matrix (ECM) of the urinary bladder from pigs for treatment of acquired urinary incontinence in dogs resistant to medical treatment. Design—Case series. Animals—9 female dogs with acquired urinary incontinence. Procedure—In 6 dogs, 30 mg of particulate ECM in 1.0 mL of a carrier consisting of glycerin and saline (0.9% NaCl) solution was injected into each of 3 equally spaced sites around the circumference of the internal urethral sphincter via an endoscopic technique. In the remaining 3 dogs (control dogs), 1.0 mL of the carrier alone was injected in 3 equally spaced sites around the circumference of the internal urethral sphincter in a similar manner. Results—For dogs treated with the ECM, median duration of urinary continence following treatment was 168 days (range, 84 to 616 days), whereas for the control dogs, median duration of urinary continence following the procedure was 14 days (range, 7 to 31 days). Two of the...