Synthesis methods of glycosyl mercaptan and auranofin

The present invention discloses synthesis methods of glycosyl mercaptan and auranofin. The glycosyl mercaptan synthesis method comprises: (1) dissolving sulfur acetyl protecting saccharide, mercaptan and a weak alkali in an organic solvent to obtain a raw material mixing liquid; and (2) carrying out a reaction on the raw material mixing liquid for 1-24 h at a room temperature, and carrying out extraction purification on the reaction product to obtain the glycosyl mercaptan. The auranofin synthesis method comprises: A, dissolving 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl mercaptan and triethyl phosphorus gold trichloride in an organic solvent, carrying out an ice bath, adding an aqueous solution of an alkali metal weak acid salt, and continuously stirring to obtain a reaction liquid; and B, carrying out a nucleophilic substitution reaction on the reaction liquid at a room temperature to obtain a crude reaction product, and carrying out extraction purification to obtain the pure auranofin. The method of the present invention has characteristics of mild reaction condition, high yield, good adaptability, and low production cost.