Sufentanil modifies the antibacterial activity of bupivacaine and ropivacaine

Purpose The purpose of our study was to investigate the effect on the growth ofEscherichia coli (E. coli), Staphylococcus aureus (S. aureus), andEnterococcus faecalis (E. faecalis) of bupivacaine at a final concentration of 0.77 mg·mL−1, ropivacaine at 1.2 mg·mL−1, and sufentanil at 0.38 and 0.5 μg·mL−1 (alone or in combination with bupivacaine and ropivacaine).