Tales from the Crypt: Evidence for Heptahelical Receptor Signaling in the Endocytic Pathway

In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al . discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This Perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.