Comparison of the Results of Miniature Pig and Human Acellular Dermal Matrix(ADM) Grafting

Objective To compare the results of BAMA miniature pig and human acellular dermal matrix(ADM) grafting,based on a Wistar rat full-thickness skin wound model.Methods ADMs were obtained from BAMA miniature pig and human skin removed by dermatotome,and irradiated for a dose of 30 kGy.Then,the two ADMs were used to cover the full-thickness skin wound in Wistar rats.The changes of wound surface,including biocompatibility,process of vascularization and shrinkage rate,were recorded until concrescence.Results The wound surface of BAMA miniature pig and human ADM grafting healed about 1 month later.Histological examination showed that inflammatory reaction on BAMA miniature pig ADM was more prominent than that on human ADM.Also,vascularization and fibroblasts immigration into BAMA miniature pig ADM was slower than those into human ADM.However,there was no significant difference between their shrinkage rates.Conclusion The results of this study indicated that biocompatibility and vascularization of BAMA miniature pig ADM is not as good as those of human ADM,mainly caused by the difference between their protein composition.