Validation of Risk Prediction Models to Inform Clinical Decisions After Acute Kidney Injury.

Abstract Rationale & Objective There is limited evidence to guide follow-up after acute kidney injury (AKI). Knowledge gaps include which patients to prioritize, at what time point, and for mitigation of which outcomes. In this study, we sought to compare the net-benefit of risk model-based clinical decisions following AKI. Study Design External validation of two risk models of AKI outcomes: 1) the Grampian (UK) – Aberdeen AKI readmissions model and 2) the Alberta (Canada) Kidney Disease risk model of CKD G4-G5). Process mining to delineate existing care pathways. Setting and Participants Validation was based on data from adult hospital survivors of AKI from Grampian (UK), 2011-2013. Predictors KDIGO-based measures of AKI severity and comorbidities specified in the original models. Outcomes (1) death or readmission within 90 days for all hospital survivors; and (2) progression to new CKD G4-G5 for patients surviving at least 90-days after AKI. Analytical Approach Decision curve analysis to assess the “net-benefit” of use of risk models to guide clinical care compared to alternative approaches (e.g. prioritizing all AKI, severe AKI, or only those without kidney recovery). Results 26575 of 105461 hospital survivors in Grampian were included for validation of the death or readmission model, mean (SD) age 60.9 years (19.8); and 9382 for the CKD G4-G5 model, mean age 67.2 years (15.4). Both models discriminated well (AUC 0.77 and 0.86 respectively). Decision curve analysis showed greater net-benefit for follow up of all AKI than only severe AKI in most situations. Both original and refitted models provided superior net-benefit to any other decision strategy. In process mining of all hospital discharges, 41% of readmissions and deaths occurred among people recovering after AKI. 1464/3776 (39%) people readmitted after AKI had received no intervening monitoring. Limitations Both original models overstated risks indicating a need for regular updating. Conclusions Follow up after AKI has potential net-benefit for pre-empting readmissions, death and subsequent CKD progression. Decisions could be improved by using risk models and by focusing on AKI across a full spectrum of severity. The current lack of monitoring among many with poor outcomes indicates possible opportunities for implementation of decision support.