Syntheses of Two Potential Ligands for Tc-99m Labeling as Diagnosis Agents of Alzheimer's Disease†

Two types of ligands-biphenyl and stilbene derivatives, which can be labeled with Tc-99m for the diagnosis of Alzheimer's disease (AD) have been synthesized successfully. The key steps in these two syntheses involved Suzuki reaction and Wittig reaction respectively. The new discovered debromination reaction may be expanded to the compounds with double or triple bond adjacent to the carbon atom bearing the bromine atoms. These types of syntheses provide a route to a series of biphenyl and stilbene derivatives that will benefit the search of new imaging agents for AD.