Familial paroxysmal rhabdomyolysis in children: A myoglobinuric syndrome

Abstract A study is presented of a family in which three male members have had spontaneous rhabdomyolysis and myoglobinuria. Increased phosphorylase activity in the skeletal muscle of one child and his mother, and in the leukocytes of another affected child, was found. These findings are discussed and comments are made on rhabdomyolysis and myoglobinuria in general.