Cu(II) and Zn(II) complexes from a thiosemicarbazone derivative: Investigating the intermolecular interactions, crystal structures and cytotoxicity

Abstract Two complexes of Cu(II) and Zn(II) were prepared from a thiosemicarbazone derivative (H2esct) using their corresponding metal acetates and 2,2′-bipyridine as base. The complexes were characterized by elemental analyses, UV–visible, FT-IR and NMR spectroscopy. The structure of the thiosemicarbazone derivative and its five coordinated complexes were also determined by the single crystal X-ray diffraction study. Copper complex got crystallized in triclinic P 1 ¯ space group and zinc complex in monoclinic P21/c space group. The crystal structures of the complexes exhibited different types of intermolecular interactions, which have been further analyzed by Hirshfeld surface analysis and fingerprint plots. The in vitro cytotoxicity against Dalton lymphoma ascites cell lines showed that the Zn(II) and Cu(II) complexes are more cytotoxic than their corresponding proligands.