Elevated circulating luteinizing hormone levels are associated with diabetic macroalbuminuria in Chinese men and postmenopausal women: a cross-sectional study.

2020 
BACKGROUD Associations between sex hormones and diabetic vascular complications was recently studied, but the role luteinizing hormone (LH), playing in diabetic kidney disease (DKD) remains uncertain. We aimed to investigate the relationship of LH and DKD in Chinese men and postmenopausal women with type 2 diabetes mellitus (T2DM). METHODS Data were collected from 1775 T2DM men and postmenopausal women in hospital. The odds ratios (OR) and corresponding 95% confidence intervals (CI) in relation to LH quartiles were obtained by multiple logistic regression analysis. RESULTS LH levels were significantly higher in patients with macroalbuminuria than those with microalbuminuria, but not in patients with microalbuminuria than those with normoalbuminuria. Consistently, LH in those with estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2 were significantly higher than those with eGFR≥60 mL/min/1.73m2 . The prevalence of macroalbuminuria was obviously increased for subjects of the fourth quartile of LH vs the first to third quartile (20.4% vs 6.2%, 8.0%, 12.2% in men; 25.3% vs 5.5%, 3.8%, 9.3% in postmenopausal women). Multivariate logistic regression demonstrated that subjects within the highest quartile of LH had higher odds of macroalbuminuria than those within the lowest quartile (OR 4.00, 95%CI 1.87-8.55 for men; OR 9.62, 95%CI 3.42-27.08 for postmenopausal women), independent of age, diabetes duration or other metabolic factors. The area under curve (AUC) for detecting macroalbuminuria based on LH was 0.662 for men, and 0.767 for postmenopausal women. CONCLUSION High LH levels are positively associated with established DKD among Chinese men and postmenopausal women. Elevated LH may be a promising clinical factor for identifying established DKD. This article is protected by copyright. All rights reserved.
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