Polymorphisms of Tumor Necrosis Factor and Myeloperoxidase Genes in Patients with Chronic Renal Failure on Peritoneal Dialysis

Background: Analyzing the molecular variants of immunological system genes helps to develop our understanding of the pathogenesis of several diseases. The tumor necrosis factor (TNF) is an important cytokine of cellular response and inflammation. The TNF gene is located within the MHC region on chromosome 6p21.3. Single nucleotide polymorphisms in the TNF gene, such as the one at a position −308, probably have a direct influence on TNF production. Myeloperoxidase, a heme enzyme, participates in micro-organism killing. The myeloperoxidase (MPO) gene is located on chromosome 17. In the promoter region, at position −463, G to A transition has been found, which causes decreased gene expression.