Establishing tissue-specific gene expression in skeletal muscle

yod is a master regulator of the skeletal muscle gene expression program. chip-seq analysis has recently revealed that yod binds to a large mnumber of genomic loci in differentiating myoblasts, yet only activates transcrip-tion at a subset of these genes. ere we hdiscuss recent data suggesting that the ability of myod to mediate gene expres-sion is regulated through the function of polycomb and t rithorax Group proteins. Based on studies of the muscle-specific