Endoscopic ultrasoud-guided fine-needle aspiration biopsy in diagnosis of cystic pancreatic lesions

Objective To investigate the diagnostic value of endoscopic ultrasonography-guided fine needle aspiration （EUS-FNA） and cell blocks for cystic pancreatic lesions. Methods Clinical data of 15 patients with cystic pancreatic lesions who underwent EUS-FNA from January 2010 to December 2012, in which 8 patients accepted the examination of liquid-based cytology （LBC） and cell blocks, were retrospec- tively reviewed. The patients also accepted CT, MRI and B-ultrasound before EUS-FNA, and the results of 4 examinations were compared. Results Among 15 cystic pancreatic lesions, there were 7 cases of pan- creatic pseudocyst, 2 cases of mueinous cyst adenoma, 1 case of intraductal papillary mucinous neoplasm （IPMN） , 3 cases of pancreatic cancer and 2 cases of cyst adenocarcinoma. The diagnostic accuracy of tradi- tional imaging tests, EUS-FNA, LBC, cell blocks were 53.3%, 86. 7%, 75. 0% and 100. 0% respectively （P 〈 0. 05）. Compared with traditional imaging tests, the sensitivity, specificity, Youden index of EUS- FNA were higher （86. 7% , 75.0% and 0. 62 vs. 53.3% , 58.3% and 0. 12）. The sensitivity of cell blocks examination was higher than that of LBC （ 100. 0% vs. 75.0% ）. Conclusion EUS-FNA and the examina- tion of cell blocks can improve the diagnostic accuracy of pancreatic cystic lesions. Key words: Biopsy, Fine-needle ;  Endoscopic uhrasonography ;  Cytological techniques ;  Pan- creatic neoplasms