Enhanced oral absorption of pemetrexed by ion-pairing complex formation with deoxycholic acid derivative and multiple nanoemulsion formulations: preparation, characterization, and in vivo oral bioavailability and anticancer effect

Rudra Pangeni,Jeong Uk Choi,Vijay Kumar Panthi,Youngro Byun,Jin Woo Park

Enhanced oral absorption of pemetrexed by ion-pairing complex formation with deoxycholic acid derivative and multiple nanoemulsion formulations: preparation, characterization, and in vivo oral bioavailability and anticancer effect

2018

Rudra Pangeni
Jeong Uk Choi
Vijay Kumar Panthi
Youngro Byun
Jin Woo Park

Objective The current study sought to design an oral delivery system of pemetrexed (PMX), a multitargeted antifolate antimetabolite, by enhancing its intestinal membrane permeability.

Keywords:

Absorption (pharmacology)
Biochemistry
Pemetrexed
Materials science
In vivo
Deoxycholic acid
Ion
Bioavailability
Pairing
membrane permeability
Molecular biology
Pharmacology
Lipophilicity
Lewis lung carcinoma
In vitro
Antimetabolite

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