Antibacterial Activity of Enrofloxacin and Ciprofloxacin Derivatives of β‐Octaarginine

β3-Octaarginine chains were attached to the functional groups NH and CO2H of the antibacterial fluoroquinolones ciprofloxacin (1) and enrofloxacin (2), respectively, in order to find out whether the activity increases by attachment of the polycationic, cell-penetrating peptide (CPP) moiety. For comparison, simple amides, 3–5, of the two antimicrobial compounds and β3-octaarginine amide (βR8) were included in the antibacterial susceptibility tests to clarify the impact of chemical modification on the microbiological activity of either scaffold (Table).