Triiodothyronine (T3) modifies cholinergic-induced hypothermia and tremor in rats

Abstract Hypothermia and tremor responses of oxotremorine and eserine were studied in rats after several T3 treatment regimes. The T3 antagonized oxotremorine-induced hypothermia and failed to antagonize eserine hypothermic effect, but potentiated oxotremorine- and eserine-induced tremors. Acetylcholinesterase activity was not altered in T3 rats. The hypothetical mechanisms to explain changes of central cholinergic responses caused by T3 are discussed.